Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D06SJZ
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| Former ID |
DIB001705
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| Drug Name |
XB-947
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| Synonyms |
XR-469R; (+)-2(R)-[4-(7-Chloroquinoxalin-2-yloxy)phenoxy]propionic acid sodium salt; (R)-(+)-XK-469
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H15ClN2O4
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| Canonical SMILES |
CC(C(=O)OC)OC1=CC=C(C=C1)OC2=CN=C3C=CC(=CC3=N2)Cl
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| InChI |
1S/C18H15ClN2O4/c1-11(18(22)23-2)24-13-4-6-14(7-5-13)25-17-10-20-15-8-3-12(19)9-16(15)21-17/h3-11H,1-2H3
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| InChIKey |
NPUWJNOFOGQLSR-UHFFFAOYSA-N
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| CAS Number |
CAS 78104-71-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase II beta (TOP2B) | Target Info | Modulator | [2] |
| Panther Pathway | DNA replication | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours. Eur J Cancer. 2008 August; 44(12): 1684-1692. | |||
| REF 2 | XK469, a selective topoisomerase IIbeta poison. Proc Natl Acad Sci U S A. 1999 October 12; 96(21): 12168-12173. | |||
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