Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06TNG
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| Former ID |
DAP000751
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| Drug Name |
Polythiazide
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| Synonyms |
Drenusil; Nephril; Politiazida; Polythiazidum; Renese; P 2525; P-2525; Politiazida [INN-Spanish]; Polythiazidum [INN-Latin]; Renese (TN); Polythiazide (JAN/USAN/INN); Polythiazide [USAN:INN:BAN:JAN]; 2-Methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide (8CI, 9CI); 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1; 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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| Drug Type |
Small molecular drug
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| Indication | Edema [ICD-11: MG29; ICD-10: R60] | Approved | [1], [2], [3] | |
| Hypertension [ICD-11: BA00-BA04] | Approved | [1], [2], [3] | ||
| Therapeutic Class |
Antihypertensive Agents
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| Structure |
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Download2D MOL |
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| Formula |
C11H13ClF3N3O4S3
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| Canonical SMILES |
CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CSCC(F)(F)F
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| InChI |
1S/C11H13ClF3N3O4S3/c1-18-10(4-23-5-11(13,14)15)17-7-2-6(12)8(24(16,19)20)3-9(7)25(18,21)22/h2-3,10,17H,4-5H2,1H3,(H2,16,19,20)
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| InChIKey |
CYLWJCABXYDINA-UHFFFAOYSA-N
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| CAS Number |
CAS 346-18-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9968, 407633, 5015695, 7847723, 7980358, 8152991, 10519518, 14783611, 29223951, 46508633, 48423975, 49855373, 50501950, 57322494, 103589988, 103847244, 104307670, 117629237, 124893800, 127696168, 134221763, 134338037, 134975128, 137173878, 142047533, 144206688, 160964621, 164764476, 170465068, 176262226, 178103848, 179226039, 223440715, 226415374, 241076557, 250117783
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| ChEBI ID |
CHEBI:8327
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| ADReCS Drug ID | BADD_D01797 | |||
| SuperDrug ATC ID |
C03AA05
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| SuperDrug CAS ID |
cas=000346189
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Solute carrier family 12 member 3 (SLC12A3) | Target Info | Blocker | [2] |
| Pathwhiz Pathway | Kidney Function | |||
| Reactome | Cation-coupled Chloride cotransporters | |||
| WikiPathways | Transport of inorganic cations/anions and amino acids/oligopeptides | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7274). | |||
| REF 2 | The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest. 2001 Jul;108(2):215-22. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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