Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D06TOE
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| Former ID |
DAP000548
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| Drug Name |
Micafungin
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| Synonyms |
Mycamine; FK463; FK-463; Mycamine (TN); Mycamine(TM)
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| Drug Type |
Small molecular drug
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| Indication | Candidiasis [ICD-11: 1F23] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antifungal Agents
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| Company |
Astellas Pharma
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| Structure |
 |
Download2D MOL
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| Formula |
C56H71N9O23S
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| Canonical SMILES |
CCCCCOC1=CC=C(C=C1)C2=CC(=NO2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C(NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC(=C(C=C7)O)OS(=O)(=O)O)O)O)C(CC(=O)N)O)C)O)O)O
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| InChI |
1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1
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| InChIKey |
PIEUQSKUWLMALL-YABMTYFHSA-N
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| CAS Number |
CAS 235114-32-6
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:600520
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| ADReCS Drug ID | BADD_D01455 ; BADD_D01456 | |||
| SuperDrug ATC ID |
J02AX05
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Fungal 1,3-beta-glucan synthase (Fung GSC2) | Target Info | Modulator | [3] |
| KEGG Pathway | Starch and sucrose metabolism | |||
| MAPK signaling pathway - yeast | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Echinocandins: pharmacokinetic and therapeutic issues. Curr Med Res Opin. 2009 Jul;25(7):1741-50. | |||
| REF 2 | 2005 approvals: Safety first. Nature Reviews Drug Discovery 5, 92-93 (February 2006). | |||
| REF 3 | An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicrob Chemother. 2014 Apr;69(4):1065-74. | |||
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