Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07BPS
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| Former ID |
DAP000730
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| Drug Name |
Suprofen
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| Synonyms |
Maldocil; Masterfen; Profenal; Srendam; Sulproltin; Suprocil; Suprofene; Suprofenum; Suprol; Sutoprofen; R 25061; R25061; TN 762; TN762; Profenal (TN); R-25061; Suprofene [INN-French]; Suprofenum [INN-Latin]; TN-762; TYN-762P; P-2-Thenoylhydratropic acid; R-25,061; Suprofen (JAN/USP/INN); Suprofen [USAN:BAN:INN:JAN]; Alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (+-)-2-(p-(2-Thenoyl)phenyl)propionic acid; (-)-alpha-Methyl-4-(2-thienylcarbonyl)benzeneacetic acid; (R)-(Thien-2-ylcarbonyl)propionic acid; (S)-2-(4-(Thien-2-ylcarbonyl)phenyl)butyric acid; 2-(4-(2-Thenoyl)phenyl)propionsaeure; 2-(4-(2-Thienylcarbonyl)phenyl)propanoic acid; 2-[4-(thiophen-2-ylcarbonyl)phenyl]propanoic acid; 2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid; 4-(2-Thenoyl)hydratropsaeure
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| Drug Type |
Small molecular drug
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| Indication | Miosis [ICD-11: LA11.62; ICD-10: H57, H57.0; ICD-9: 379.42, 625.3] | Approved | [1], [2], [3] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C14H12O3S
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| Canonical SMILES |
CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O
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| InChI |
1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17)
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| InChIKey |
MDKGKXOCJGEUJW-UHFFFAOYSA-N
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| CAS Number |
CAS 40828-46-4
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9528, 224830, 453324, 3180764, 7672824, 7847518, 8149755, 8153294, 10321232, 11335651, 11360890, 11364051, 11366613, 11369175, 11372035, 11374691, 11377337, 11461862, 11466844, 11467964, 11485276, 11486368, 11489246, 11490743, 11492841, 11494971, 12012657, 14848020, 26612210, 26679843, 26748525, 26748526, 29224411, 46508210, 47365135, 47662231, 47736424, 47810708, 47810709, 48035064, 49698781, 49977399, 50025833, 50107425, 56459397, 56463227, 57322736, 74790379, 85787329, 92124483
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| ChEBI ID |
CHEBI:9362
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| ADReCS Drug ID | BADD_D02102 | |||
| SuperDrug ATC ID |
M01AE07
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| SuperDrug CAS ID |
cas=040828464
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Prostaglandin G/H synthase 1 (COX-1) | Target Info | Inhibitor | [4] |
| BioCyc | C20 prostanoid biosynthesis | |||
| KEGG Pathway | Arachidonic acid metabolism | |||
| Metabolic pathways | ||||
| Platelet activation | ||||
| Serotonergic synapse | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | |||
| Pathwhiz Pathway | Arachidonic Acid Metabolism | |||
| WikiPathways | Prostaglandin Synthesis and Regulation | |||
| Arachidonic acid metabolism | ||||
| Phase 1 - Functionalization of compounds | ||||
| Eicosanoid Synthesis | ||||
| Selenium Micronutrient Network | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7298). | |||
| REF 2 | Drug information of Suprofen, 2008. eduDrugs. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 4 | Differential binding mode of diverse cyclooxygenase inhibitors. J Mol Graph Model. 2002 Mar;20(5):359-71. | |||
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