Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07BXC
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| Former ID |
DIB005786
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| Drug Name |
IZONSTERIDE
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| Synonyms |
Izonsteride < Prop INN; LY-320236; (4aR,10bR)-8-(4-Ethylbenzothiazol-2-ylsulfanyl)-4,10b-dimethyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one
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| Drug Type |
Small molecular drug
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| Indication | Hirsutism [ICD-11: ED72; ICD-10: L68.0; ICD-9: 704.1] | Phase 1/2 | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C24H26N2OS2
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| Canonical SMILES |
CCC1=C2C(=CC=C1)SC(=N2)SC3=CC4=C(C=C3)C5(CCC(=O)N(C5CC4)C)C
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| InChI |
1S/C24H26N2OS2/c1-4-15-6-5-7-19-22(15)25-23(29-19)28-17-9-10-18-16(14-17)8-11-20-24(18,2)13-12-21(27)26(20)3/h5-7,9-10,14,20H,4,8,11-13H2,1-3H3/t20-,24-/m1/s1
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| InChIKey |
VMGWGDPZHXPFTC-HYBUGGRVSA-N
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| CAS Number |
CAS 176975-26-1
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Oxo-5-alpha-steroid 4-dehydrogenase (SRD5A) | Target Info | Modulator | [2], [3] |
| References | Top | |||
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| REF 1 | 5alpha-reductase activity in the prostate. Urology. 2001 Dec;58(6 Suppl 1):17-24; discussion 24. | |||
| REF 2 | Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: elevation of estradiol as possible... Urology. 2004 Jan;63(1):114-9. | |||
| REF 3 | Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5alpha-reductase. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):13-21. | |||
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