Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07BXD
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| Former ID |
DNC011420
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| Drug Name |
HI-281
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| Synonyms |
HI-281; CHEMBL290312; DDE281; AC1LAQRC; CTK7B5925; BDBM50078262; 4-[(3,5-Dimethylphenyl)methyl]-3-(methylethyl)-6-(methylthiomethylthio)hydropyridin-2-one; 4-(3,5-Dimethyl-benzyl)-3-isopropyl-6-methylsulfanylmethylsulfanyl-1H-pyridin-2-one; 4-(3,5-dimethylbenzyl)-3-(1-methylethyl)-6-{[(methylsulfanyl)methyl]sulfanyl}pyridin-2(1h)-one; 4-[(3,5-dimethylphenyl)methyl]-6-(methylsulfanylmethylsulfanyl)-3-propan-2-yl-1H-pyridin-2-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H25NOS2
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| Canonical SMILES |
CC1=CC(=CC(=C1)CC2=C(C(=O)NC(=C2)SCSC)C(C)C)C
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| InChI |
1S/C19H25NOS2/c1-12(2)18-16(9-15-7-13(3)6-14(4)8-15)10-17(20-19(18)21)23-11-22-5/h6-8,10,12H,9,11H2,1-5H3,(H,20,21)
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| InChIKey |
AGRSTTVMWWVJEL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Reverse transcriptase (HIV RT) | Target Info | Inhibitor | [1] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistan... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1593-8. | |||
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