Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07EGW
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| Former ID |
DIB011478
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| Drug Name |
AE-0047
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| Synonyms |
Calbren; Vatanidipine; Watanidipine hydrochloride; GJ-0956; (R)-(-)-AE 0047; (S)-(+)-AE 0047
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Discontinued in Preregistration | [1] | |
| Company |
Mitsubishi Pharma Corp
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| Structure |
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Download2D MOL
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| Formula |
C41H42N4O6
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| Canonical SMILES |
CC1=C(C(C(=C([O-])OC)C(=N1)C)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCC3=CC=C(C=C3)[NH+]4CCN(CC4)C(C5=CC=CC=C5)C6=CC=CC=C6
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| InChI |
1S/C41H42N4O6/c1-28-36(40(46)50-3)38(33-15-10-16-35(27-33)45(48)49)37(29(2)42-28)41(47)51-26-21-30-17-19-34(20-18-30)43-22-24-44(25-23-43)39(31-11-6-4-7-12-31)32-13-8-5-9-14-32/h4-20,27,38-39,46H,21-26H2,1-3H3
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| InChIKey |
VPQACPHDDSSGPL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Modulator | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001931) | |||
| REF 2 | AE0047-mediated calcium channel blocking in vascular smooth muscles. Gen Pharmacol. 1997 Sep;29(3):337-43. | |||
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