Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07FPR
|
|||
| Former ID |
DCL000609
|
|||
| Drug Name |
R4996
|
|||
| Indication | Neurological disorder [ICD-11: 6B60] | Phase 1 | [1] | |
| Company |
Roche
|
|||
| Structure |
 |
Download2D MOL |
||
| Formula |
C11H9ClO2
|
|||
| Canonical SMILES |
C1=CC(=CC=C1C2=CC=C(O2)CO)Cl
|
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| InChI |
1S/C11H9ClO2/c12-9-3-1-8(2-4-9)11-6-5-10(7-13)14-11/h1-6,13H,7H2
|
|||
| InChIKey |
PMHZVTQIEAIJBK-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 33342-29-9
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Neuronal acetylcholine receptor alpha-7 (CHRNA7) | Target Info | Agonist | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Cholinergic synapse | ||||
| Nicotine addiction | ||||
| Chemical carcinogenesis | ||||
| Panther Pathway | Alzheimer disease-amyloid secretase pathway | |||
| Nicotinic acetylcholine receptor signaling pathway | ||||
| Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of Roche. | |||
| REF 2 | Clinical pipeline report, company report or official report of Roche (2009). | |||
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