Drug Information
Drug General Information | Top | |||
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Drug ID |
D07HAD
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Former ID |
DCL001016
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Drug Name |
Telbermin
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Synonyms |
Telbermin (USAN/INN)
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Indication | Diabetic foot ulcer [ICD-11: BD54; ICD-9: 707] | Discontinued in Phase 2 | [1] | |
Company |
Genentech
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PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Vascular endothelial growth factor receptor 1 (FLT-1) | Target Info | Activator | [1] |
KEGG Pathway | Ras signaling pathway | |||
Rap1 signaling pathway | ||||
Cytokine-cytokine receptor interaction | ||||
HIF-1 signaling pathway | ||||
Endocytosis | ||||
PI3K-Akt signaling pathway | ||||
Focal adhesion | ||||
Transcriptional misregulation in cancer | ||||
Rheumatoid arthritis | ||||
Pathway Interaction Database | Glypican 1 network | |||
HIF-2-alpha transcription factor network | ||||
S1P3 pathway | ||||
VEGF and VEGFR signaling network | ||||
VEGFR1 specific signals | ||||
Signaling events mediated by VEGFR1 and VEGFR2 | ||||
Reactome | Neurophilin interactions with VEGF and VEGFR | |||
VEGF binds to VEGFR leading to receptor dimerization | ||||
WikiPathways | Focal Adhesion | |||
Signaling by VEGF | ||||
Angiogenesis |
References | Top | |||
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REF 1 | Emerging drugs for diabetic foot ulcers. Expert Opin Emerg Drugs. 2006 Nov;11(4):709-24. |
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