Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07ILP
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| Former ID |
DNC000028
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| Drug Name |
10-hydroxycamptothecin
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| Synonyms |
10-Hydroxycamptothecin; 19685-09-7; (S)-10-Hydroxycamptothecin; Hydroxycamptothecin; 10-hydroxycamptothecine; 10-Hydroxy camptothecin; Hydroxycamptothecine; Camptothecin, hydroxy-; 10-Hydroxy-Camptothecin; (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Camptothecin, 10-hydroxy-; Camptothecine, 10-hydroxy-; UNII-9Z01632KRV; NSC 107124; HCPT; (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; (S)-10-Hydroxycamptothecin hydrate; NSC107124
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C20H16N2O5
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| Canonical SMILES |
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
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| InChI |
1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
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| InChIKey |
HAWSQZCWOQZXHI-FQEVSTJZSA-N
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| CAS Number |
CAS 19685-09-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
407052, 645392, 8140019, 10228777, 11342034, 11362217, 11364533, 11367095, 11369657, 11372600, 11375589, 11377819, 11404568, 11485555, 11487619, 11489476, 11491436, 11493629, 11495453, 12015125, 12173672, 16124509, 26612627, 26680421, 26750003, 26758893, 44427566, 47348452, 48392929, 49831587, 50028362, 50107786, 50122774, 53787862, 53790463, 57336414, 80013607, 81093235, 85788508, 89360248, 92721280, 96024160, 103071286, 103082955, 103170545, 103922002, 104420324, 117586316, 124636619, 124891994
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| ChEBI ID |
CHEBI:81395
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | DNA topoisomerase I (TOP1) | Target Info | Inhibitor | [1] |
| NetPath Pathway | IL2 Signaling Pathway | |||
| Panther Pathway | DNA replication | |||
| Pathway Interaction Database | Caspase Cascade in Apoptosis | |||
| WikiPathways | Integrated Pancreatic Cancer Pathway | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways. Int J Oncol. 1998 Apr;12(4):793-804. | |||
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