Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07JHJ
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| Former ID |
DIB012553
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| Drug Name |
IGANIDIPINE HYDROCHLORIDE
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| Synonyms |
NKY-722; Iganidipine hydrochloride; Rac-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[3-(4-allyl-1-piperazinyl)-2,2-dimethylpropyl] 5-methyl diester dihydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Discontinued in Phase 1 | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C28H40Cl2N4O6
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| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)OCC(C)(C)CN2CCN(CC2)CC=C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC.Cl.Cl
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| InChI |
1S/C28H38N4O6.2ClH/c1-7-11-30-12-14-31(15-13-30)17-28(4,5)18-38-27(34)24-20(3)29-19(2)23(26(33)37-6)25(24)21-9-8-10-22(16-21)32(35)36;;/h7-10,16,25,29H,1,11-15,17-18H2,2-6H3;2*1H
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| InChIKey |
PJGTYHKZUAHNHC-UHFFFAOYSA-N
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| CAS Number |
CAS 117241-46-0
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Calcium channel unspecific (CaC) | Target Info | Blocker | [2], [3] |
| References | Top | |||
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| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000292) | |||
| REF 2 | Improving effects of topical administration of iganidipine, a new calcium channel blocker, on the impaired visual evoked potential after endothelin-1 injection into the vitreous body of rabbits. CurrEye Res. 2000 Feb;20(2):101-8. | |||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
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