Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07JOS
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| Former ID |
DIB013411
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| Drug Name |
NS-004
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| Synonyms |
NS004; NS-004; NS-O04; 1-(5-Chloro-2-hydroxyphenyl)-5-trifluoromethyl-1,3-dihydrobenzoimidazol-2-one; WYLYBVMNGZOYOH-UHFFFAOYSA-N; AC1NSKFZ; ZINC5663; SCHEMBL8911620; GTPL4271; CHEMBL375448; SCHEMBL3102522; KB-09311; 1-[2-hydroxy-5-chlorophenyl]-5-trifluoromethyl-2-benzimidazolone; 3-(5-chloro-2-hydroxyphenyl)-6-(trifluoromethyl)-1H-benzimidazol-2-one; 2H-benzimidazol-2-one, 1-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-5-(trifluoromethyl)-; 1,3-dihydro-1-(5-chloro-2-hydroxyphenyl)-5-trifluoromethyl-2H-benzimidazol-2-one
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD-11: BA00-BA04; ICD-9: 401] | Terminated | [1], [2] | |
| Company |
NeuroSearch A/S
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| Structure |
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Download2D MOL |
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| Formula |
C14H8ClF3N2O2
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| Canonical SMILES |
C1=CC2=C(C=C1C(F)(F)F)NC(=O)N2C3=C(C=CC(=C3)Cl)O
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| InChI |
1S/C14H8ClF3N2O2/c15-8-2-4-12(21)11(6-8)20-10-3-1-7(14(16,17)18)5-9(10)19-13(20)22/h1-6,21H,(H,19,22)
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| InChIKey |
WYLYBVMNGZOYOH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Potassium channel unspecific (KC) | Target Info | Opener | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4271). | |||
| REF 2 | Effects of K+ channel inhibitors and antagonists on NS-004 evoked relaxations in guinea-pig isolated trachea. Fundam Clin Pharmacol. 1997;11(1):78-82. | |||
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