Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07MGA
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| Former ID |
DAP001306
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| Drug Name |
Hesperetin
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| Synonyms |
Hesperin; Hesperitin; TNP00238; YSO2; Cyanidanon 4'-methyl ether 1626; Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN); Flavanone, 3',5,7-trihydroxy-4'-methoxy-(VAN) (8CI); (-)-hesperetin; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one; (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; (S)-2,3-Dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone; (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3',5,7-Trihydroxy-4'-methoxyflavanone; 3',5,7-Trihydroxy-4-methoxyflavanone; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-(9CI); 5,7,3'-Trihydroxy-4'-methoxyflavanone
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| Drug Type |
Small molecular drug
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| Indication | High blood cholesterol level [ICD-11: 5C80.00; ICD-10: E78.0; ICD-9: 272] | Approved | [1] | |
| Therapeutic Class |
Anticholesteremic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C16H14O6
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| Canonical SMILES |
COC1=C(C=C(C=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O
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| InChI |
1S/C16H14O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-6,14,17-19H,7H2,1H3/t14-/m0/s1
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| InChIKey |
AIONOLUJZLIMTK-AWEZNQCLSA-N
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| CAS Number |
CAS 520-33-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4847, 597194, 877412, 8149172, 8195111, 10321847, 11112384, 11112385, 11336214, 11361453, 11363075, 11365637, 11368199, 11372127, 11375448, 11376361, 11462425, 11466152, 11467272, 11485481, 11485843, 11489609, 11490919, 11493749, 11493995, 11537620, 16889621, 24895619, 26613332, 26680108, 26744164, 26754195, 26754196, 29204220, 43128472, 46507998, 47365297, 47365298, 47440361, 47515405, 47515406, 47885508, 47959861, 48035231, 48110539, 48259342, 48421825, 49698360, 50069543, 50091682
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| ChEBI ID |
CHEBI:28230
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Diacylglycerol acyltransferase 1 (DGAT1) | Target Info | Inhibitor | [2] |
| BioCyc | Triacylglycerol biosynthesis | |||
| KEGG Pathway | Glycerolipid metabolism | |||
| Retinol metabolism | ||||
| Metabolic pathways | ||||
| Fat digestion and absorption | ||||
| Pathwhiz Pathway | Retinol Metabolism | |||
| Reactome | Acyl chain remodeling of DAG and TAG | |||
| Triglyceride Biosynthesis | ||||
| WikiPathways | Vitamin A and Carotenoid Metabolism | |||
| Statin Pathway | ||||
| Triacylglyceride Synthesis | ||||
| Glycerophospholipid biosynthesis | ||||
| Fatty acid, triacylglycerol, and ketone body metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Hesperetin, 2008. eduDrugs. | |||
| REF 2 | In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens. Planta Med. 2004 Mar;70(3):258-60. | |||
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