Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07MPJ
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| Former ID |
DIB003903
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| Drug Name |
A-75925
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| Synonyms |
A-74704; A-76928; A-77003; Protease inhibitors, Abbott
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| Drug Type |
Small molecular drug
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| Indication | Virus infection [ICD-11: 1A24-1D9Z] | Discontinued in Phase 2 | [1] | |
| Company |
Abbott Laboratories
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| Structure |
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Download2D MOL |
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| Formula |
C44H54N4O8
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| Canonical SMILES |
CC(C)C(C(=O)NC(CC1=CC=CC=C1)C(C(C(CC2=CC=CC=C2)NC(=O)C(C(C)C)NC(=O)OCC3=CC=CC=C3)O)O)NC(=O)OCC4=CC=CC=C4
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| InChI |
1S/C44H54N4O8/c1-29(2)37(47-43(53)55-27-33-21-13-7-14-22-33)41(51)45-35(25-31-17-9-5-10-18-31)39(49)40(50)36(26-32-19-11-6-12-20-32)46-42(52)38(30(3)4)48-44(54)56-28-34-23-15-8-16-24-34/h5-24,29-30,35-40,49-50H,25-28H2,1-4H3,(H,45,51)(H,46,52)(H,47,53)(H,48,54)/t35-,36-,37-,38-,39+,40+/m0/s1
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| InChIKey |
TZRRVSCDIPHXHN-RRUVMKMCSA-N
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| CAS Number |
CAS 129467-48-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Human immunodeficiency virus Protease (HIV PR) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003337) | |||
| REF 2 | Solvation studies of DMP323 and A76928 bound to HIV protease: analysis of water sites using grand canonical Monte Carlo simulations. Protein Sci. 1998 Mar;7(3):573-9. | |||
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