Drug Information
Drug General Information | Top | |||
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Drug ID |
D07SGB
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Former ID |
DIB005245
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Drug Name |
ABT-299
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Synonyms |
A-85783
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Drug Type |
Small molecular drug
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Indication | Sepsis [ICD-11: 1G40-1G41; ICD-10: R57.2; ICD-9: 785.52] | Discontinued in Phase 1 | [1], [2] | |
Company |
Abbott Laboratories
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Structure |
Download2D MOL |
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Formula |
C32H28ClFN4O4S
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Canonical SMILES |
CC(=O)OC[N+]1=CC=CC(=C1)C2N3C=CC(=C3CS2)C(=O)C4=CN(C5=C4C=CC(=C5)C6=CC=C(C=C6)F)C(=O)N(C)C.[Cl-]
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InChI |
1S/C32H28FN4O4S.ClH/c1-20(38)41-19-35-13-4-5-23(16-35)31-36-14-12-26(29(36)18-42-31)30(39)27-17-37(32(40)34(2)3)28-15-22(8-11-25(27)28)21-6-9-24(33)10-7-21;/h4-17,31H,18-19H2,1-3H3;1H/q+1;/p-1/t31-;/m1./s1
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InChIKey |
NKIONDJYXPXFFL-JSSVAETHSA-M
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CAS Number |
CAS 161395-35-3
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Platelet-activating factor receptor (PTAFR) | Target Info | Antagonist | [3] |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Staphylococcus aureus infection | ||||
NetPath Pathway | IL5 Signaling Pathway | |||
Leptin Signaling Pathway | ||||
Reactome | Class A/1 (Rhodopsin-like receptors) | |||
G alpha (q) signalling events | ||||
Interferon gamma signaling | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Small Ligand GPCRs | ||||
Interferon gamma signaling | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1849). | |||
REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005514) | |||
REF 3 | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. Shock. 1996 Aug;6(2):112-7. |
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