Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07TEZ
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| Drug Name |
Benzo[d]oxazole derivative 2
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| Synonyms |
PMID28454500-Compound-80
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| Drug Type |
Small molecular drug
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| Company |
Korea Institute of Radiological & Medical Sciences, S
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| Structure |
 |
Download2D MOL |
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| Formula |
C17H12N2O
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| Canonical SMILES |
C1=CC=C2C(=C1)C=CC=C2C3=NC4=C(O3)C=CC(=C4)N
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| InChI |
1S/C17H12N2O/c18-12-8-9-16-15(10-12)19-17(20-16)14-7-3-5-11-4-1-2-6-13(11)14/h1-10H,18H2
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| InChIKey |
NCQQMVULPNMPEH-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Nuclear factor erythroid 2-related factor 2 (Nrf2) | Target's Patent Info | [1] | |
| KEGG Pathway | Protein processing in endoplasmic reticulum | |||
| NetPath Pathway | IL5 Signaling Pathway | |||
| WikiPathways | Oxidative Stress | |||
| Transcriptional activation by NRF2 | ||||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Mesodermal Commitment Pathway | ||||
| Aryl Hydrocarbon Receptor | ||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | ||||
| Arylhydrocarbon receptor (AhR) signaling pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785. | |||
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