Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07YLK
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| Former ID |
DCL000862
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| Drug Name |
LE-300
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| Synonyms |
L 8401; LE 300; 7-Methyl-6,7,8,9,14,15-hexahydro-5H-benz[d]indolo[2,3-g]azecine
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Preclinical | [1] | |
| Company |
Sanofi-Aventis
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| Structure |
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Download2D MOL |
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| Formula |
C20H22N2
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| Canonical SMILES |
CN1CCC2=CC=CC=C2CC3=C(CC1)C4=CC=CC=C4N3
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| InChI |
1S/C20H22N2/c1-22-12-10-15-6-2-3-7-16(15)14-20-18(11-13-22)17-8-4-5-9-19(17)21-20/h2-9,21H,10-14H2,1H3
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| InChIKey |
YEWGIGCYIAMFMA-UHFFFAOYSA-N
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| CAS Number |
CAS 274694-98-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
6400836, 9649719, 11111388, 11114176, 14751316, 17405260, 24278519, 35651298, 48243366, 50104929, 50104930, 50596018, 53777805, 56463488, 57356947, 85231116, 85788766, 90341417, 91721352, 92304138, 103256967, 103987265, 112895614, 121361663, 124360335, 124749926, 124800665, 124880585, 124880586, 125541614, 129785900, 134345123, 135698238, 162023325, 162247453, 163123364, 163564653, 178126669, 204370243, 237659418, 241056122, 241182619, 241375575
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| ChEBI ID |
CHEBI:92030
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine D5 receptor (D5R) | Target Info | Antagonist | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | ||||
| Dopaminergic synapse | ||||
| Panther Pathway | Dopamine receptor mediated signaling pathway | |||
| Reactome | Dopamine receptors | |||
| G alpha (s) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. | |||
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