Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07YWY
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| Former ID |
DIB013420
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| Drug Name |
Nafronyl
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| Synonyms |
Nafronyl oxalate; 3200-06-4; Naftidrofuryl oxalate; Nafronyl oxalate salt; 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate; Naftidrofuryl (oxalate); Dusodril; Dubimax; Praxilene; Iridus; LS-121; EU-1806; DSSTox_RID_80935; DSSTox_CID_25533; DSSTox_GSID_45533; naftidrofuryl hydrogen oxalate; CHEMBL1439099; alpha-[1-Naphthylmethyl]-2-tetrahydrofuranpropionic acid diethylaminoethyl ester; SMR000539007; Nafronyl oxalate salt, analytical standard; CAS-3200-06-4; NSC225233; LS 121
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| Drug Type |
Small molecular drug
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| Indication | Cerebrovascular ischaemia [ICD-11: 8B1Z; ICD-10: I67.8; ICD-9: 434.91] | Approved | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C24H33NO3
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| Canonical SMILES |
CCN(CC)CCOC(=O)C(CC1CCCO1)CC2=CC=CC3=CC=CC=C32
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| InChI |
1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3
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| InChIKey |
KBAFPSLPKGSANY-UHFFFAOYSA-N
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| CAS Number |
CAS 31329-57-4
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:91817
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bacteroidales | ||||
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Studied Microbe: Bacteroides fragilis NCTC 9343
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Bacteroides fragilis NCTC 9343 (log2FC = -0.364; p = 0.03). | |||
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Studied Microbe: Bacteroides uniformis ATCC 8492
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Bacteroides uniformis ATCC 8492 (log2FC = -0.474; p = 0.006). | |||
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Studied Microbe: Bacteroides vulgatus ATCC 8482
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[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Bacteroides vulgatus ATCC 8482 (log2FC = -0.581; p = 0.012). | |||
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Studied Microbe: Odoribacter splanchnicus
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Odoribacter splanchnicus (log2FC = -0.39; p = 0.03). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Bifidobacteriales | ||||
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Studied Microbe: Bifidobacterium ruminantium
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Bifidobacterium ruminantium (log2FC = -0.338; p = 0.015). | |||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Blautia hansenii DSM20583
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|
[2] | |||
| Hierarchy | ||||
| Experimental Method | High-throughput screening | |||
| Description | Nafronyl oxalate can be metabolized by Blautia hansenii DSM20583 (log2FC = -0.409; p = 0.049). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT receptor (5HTR) | Target Info | Modulator | [1] |
| References | Top | |||
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| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019 Jun;570(7762):462-467. | |||
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