Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D07ZCK
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| Former ID |
DNC011521
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| Drug Name |
ZK-93423
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| Synonyms |
ZK 93423; 83910-44-5; ZK93423; ZK 93 423; 6-Benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 4-(methoxymethyl)-6-(phenylmethoxy)-, ethyl ester; ALBKMJDFBZVHAK-UHFFFAOYSA-N; PDSP1_001754; AC1L3TNV; AC1Q64YI; CHEMBL10947; GTPL4346; SCHEMBL7117282; CHEMBL1518572; BDBM85039; CHEBI:92593; ZINC5857871; PDSP2_001737; PDSP1_001771; ethyl 6-(benzyloxy)-4-(methoxymethyl)-9h-; BDBM50007553; PDSP2_001754; CAS_121926; NSC_121926
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| Drug Type |
Small molecular drug
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| Indication | Epileptic seizures [ICD-11: 8A61-8A6Z; ICD-9: 345.9, 780.3] | Phase 3 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H22N2O4
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| Canonical SMILES |
CCOC(=O)C1=NC=C2C(=C1COC)C3=C(N2)C=CC(=C3)OCC4=CC=CC=C4
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| InChI |
1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3
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| InChIKey |
ALBKMJDFBZVHAK-UHFFFAOYSA-N
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| CAS Number |
CAS 83910-44-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7980912, 10239868, 14829922, 26755019, 29302418, 47434919, 47657169, 48179786, 48179787, 50070370, 50071017, 57339848, 80294733, 103825000, 103920823, 104414616, 117578843, 127422224, 134348726, 135076454, 136351139, 137010628, 160687891, 162224540, 177748540, 178101163, 179293780, 224986468, 232769861, 241147277
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| ChEBI ID |
CHEBI:92593
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [3] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [3] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [3] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4346). | |||
| REF 2 | Abecarnil enhances GABA-induced currents in acutely isolated cerebellar Purkinje cells. Neuropharmacology. 1995 Feb;34(2):157-63. | |||
| REF 3 | Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carbolin... J Med Chem. 1990 Mar;33(3):1062-9. | |||
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