Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07ZMG
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| Drug Name |
Thiazole carboxamide derivative 29
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| Synonyms |
PMID25684022-Compound-WO2012036974 24(45)
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| Indication | Metastatic cancer [ICD-11: 2D50-2E2Z] | Patented | [1] | |
| Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C76-C80; ICD-9: 140-229] | Patented | [1] | ||
| Company |
MERCK SHARP & DOHME CORP. TSUI, Hon-Chung PALIWAL, Sunil FISCHMANN, Thierry Olivier
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| Structure |
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Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Pyruvate dehydrogenase kinase 1 (PDHK1) | Target's Patent Info | [1] | |
| KEGG Pathway | HIF-1 signaling pathway | |||
| Axon guidance | ||||
| Central carbon metabolism in cancer | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PDK1 disruptors and modulators: a patent review.Expert Opin Ther Pat. 2015 May;25(5):513-37. | |||
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