Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08BTB
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| Drug Name |
protirelin
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| Synonyms |
24305-27-9; Hirtonin; TRH-SR, Takeda; protirelin
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| Drug Type |
Small molecular drug
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| Indication | Central nervous system disease [ICD-11: 8A04-8D87] | Approved | [1] | |
| Therapeutic Class |
Neurology Agents
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| Company |
Abbott Laboratories Pharmaceutical Products Div
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| Structure |
 |
Download2D MOL |
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| Formula |
C16H22N6O4
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| Canonical SMILES |
C1CC(N(C1)C(=O)C(CC2=CN=CN2)NC(=O)C3CCC(=O)N3)C(=O)N
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| InChI |
1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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| InChIKey |
XNSAINXGIQZQOO-SRVKXCTJSA-N
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| CAS Number |
CAS 24305-27-9
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:35940
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| ADReCS Drug ID | BADD_D01871 ; BADD_D02209 | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Thyrotropin-releasing hormone receptor (TRHR) | Target Info | Modulator | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Panther Pathway | Thyrotropin-releasing hormone receptor signaling pathway | |||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Company report (takeda) | |||
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