Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08CMW
|
|||
| Former ID |
DNC012193
|
|||
| Drug Name |
6-Phenylaminomethyl-quinazoline-2,4-diamine
|
|||
| Synonyms |
CHEMBL80746; 6-(anilinomethyl)quinazoline-2,4-diamine; 27133-39-7; AC1LAG5J; 6-Phenylaminomethyl-quinazoline-2,4-diamine; SCHEMBL4788363; CTK0I5781; DTXSID30333156; ZINC3814839; BDBM50101637; [(2,4-Diaminoquinazolin-6-yl)methyl]phenylamine; 2,4-Quinazolinediamine, 6-[(phenylamino)methyl]-
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C15H15N5
|
|||
| Canonical SMILES |
C1=CC=C(C=C1)NCC2=CC3=C(C=C2)N=C(N=C3N)N
|
|||
| InChI |
1S/C15H15N5/c16-14-12-8-10(6-7-13(12)19-15(17)20-14)9-18-11-4-2-1-3-5-11/h1-8,18H,9H2,(H4,16,17,19,20)
|
|||
| InChIKey |
SQHNSLWKFCXHKZ-UHFFFAOYSA-N
|
|||
| CAS Number |
CAS 27133-39-7
|
|||
| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. J Med Chem. 2003 Jul 31;46(16):3455-62. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.