Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08CQQ
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| Former ID |
DNC014649
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| Drug Name |
NSC-679036
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| Synonyms |
NSC-679036; CHEMBL49827; 2-(3-chlorophenyl)-6-methyl-1,8-naphthyridin-4(1H)-one; NSC679036; AC1L8S0Y; SCHEMBL7925200; CTK8C9852; ZINC5503957; 1, 2-(3-chlorophenyl)-6-methyl-; BDBM50059961; NCI60_028235; 2-(3-chlorophenyl)-6-methyl-1H-1,8-naphthyridin-4-one; 2-(3-Chloro-phenyl)-6-methyl-1H-[1,8]naphthyridin-4-one; 1,8-Naphthyridin-4(1H)-one, 2-(3-chlorophenyl)-6-methyl-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H11ClN2O
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| Canonical SMILES |
CC1=CC2=C(NC(=CC2=O)C3=CC(=CC=C3)Cl)N=C1
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| InChI |
1S/C15H11ClN2O/c1-9-5-12-14(19)7-13(18-15(12)17-8-9)10-3-2-4-11(16)6-10/h2-8H,1H3,(H,17,18,19)
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| InChIKey |
FSWIIQLXZOJBSF-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tubulin (TUB) | Target Info | Inhibitor | [1] |
| Tubulin beta (TUBB) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Phagosome | |||
| Gap junction | ||||
| Pathogenic Escherichia coli infection | ||||
| NetPath Pathway | FSH Signaling Pathway | |||
| TCR Signaling Pathway | ||||
| EGFR1 Signaling Pathway | ||||
| Panther Pathway | Cytoskeletal regulation by Rho GTPase | |||
| Huntington disease | ||||
| Reactome | Regulation of PLK1 Activity at G2/M Transition | |||
| Loss of Nlp from mitotic centrosomes | ||||
| Recruitment of mitotic centrosome proteins and complexes | ||||
| Loss of proteins required for interphase microtubule organization?from the centrosome | ||||
| Anchoring of the basal body to the plasma membrane | ||||
| WikiPathways | Parkin-Ubiquitin Proteasomal System pathway | |||
| Pathogenic Escherichia coli infection | ||||
| Mitotic G2-G2/M phases | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubul... J Med Chem. 1997 Sep 12;40(19):3049-56. | |||
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