Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08CTT
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| Former ID |
DAP001366
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| Drug Name |
Dimethindene
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| Synonyms |
Dimethpyrindene; Dimethylpyrindene; Dimetindene; Dimetindeno; Dimetindenum; Fengel; Fenistil; Forhistal; Foristal; Pecofenil; Triten; Z 2001; Dimetindene (INN); Dimetindene [INN:BAN]; Dimetindeno [INN-Spanish]; Dimetindenum [INN-Latin]; Fenistil (TN); Dimethyl{2-[3-(2-pyridylethyl)inden-2-yl]ethyl}amine; N,N-Dimethyl-3-(1-(2-pyridyl)ethyl)inden-2-ethylamin; N,N-Dimethyl-N-(3-(1-(2-pyridyl)ethyl)-2-indenylethyl)amin; N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine; 1H-Indene-2-ethanamine, N,N-dimethyl-3-(1-(2-pyridinyl)ethyl)-(9CI); 2-(1-(2-(2-Dimethylaminoethyl)inden-3-yl)ethyl)pyridine
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| Drug Type |
Small molecular drug
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| Indication | Respiratory allergy [ICD-11: 4A80; ICD-10: J39.3] | Approved | [1], [2] | |
| Therapeutic Class |
Antiallergic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C20H24N2
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| Canonical SMILES |
CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C
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| InChI |
1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3
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| InChIKey |
MVMQESMQSYOVGV-UHFFFAOYSA-N
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| CAS Number |
CAS 5636-83-9
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| PubChem Compound ID | ||||
| PubChem Substance ID |
615229, 7547415, 8166093, 10527461, 16889015, 29289221, 48415902, 49833540, 50032411, 57331006, 75533068, 96024549, 99445271, 103188199, 104354442, 117521890, 119525888, 126410956, 128653820, 131342026, 134224440, 134338577, 134987134, 137113985, 141522592, 142679137, 152104464, 160969708, 179225227, 184545933, 226408700, 249924793, 252348299
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| ChEBI ID |
CHEBI:135222
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| SuperDrug ATC ID |
D04AA13; R06AB03
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| SuperDrug CAS ID |
cas=005636839
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Antagonist | [1], [3], [4], [5] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Prescription and safety of dimethindene maleate micropellet capsules in Hungary. Orv Hetil. 2004 Feb 15;145(7):327-9. | |||
| REF 2 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 3 | Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors. J Recept Signal Transduct Res. 2009;29(2):84-93. | |||
| REF 4 | Effects of dimethindene maleate nasal spray on the quality of life in seasonal allergic rhinitis. Rhinology. 2003 Sep;41(3):159-66. | |||
| REF 5 | Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102. | |||
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