Drug Information
Drug General Information | Top | |||
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Drug ID |
D08CZT
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Former ID |
DNC003968
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Drug Name |
2-Phenyl-3-piperidin-4-yl-1H-indole
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Synonyms |
221109-26-8; 2-PHENYL-3-(PIPERIDIN-4-YL)-1H-INDOLE; 2-Phenyl-3-(4-piperidinyl)-1H-indole; 2-Phenyl-3-piperidin-4-yl-1H-indole; CHEMBL295559; SCHEMBL7962369; CTK4E8621; DTXSID60432328; FWPAVENSJPMGJO-UHFFFAOYSA-N; ZINC2580888; CP-220; ANW-46494; BDBM50095050; AKOS015898489; AJ-42917; 3-(Piperidin-4-yl)-2-phenyl-1H-indole; 1H-Indole,2-phenyl-3-(4-piperidinyl)-; TC-135239; ST2404535; KB-231980; AX8078102; W4568; FT-0707553; AM20030371; P13451
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C19H20N2
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Canonical SMILES |
C1CNCCC1C2=C(NC3=CC=CC=C32)C4=CC=CC=C4
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InChI |
1S/C19H20N2/c1-2-6-15(7-3-1)19-18(14-10-12-20-13-11-14)16-8-4-5-9-17(16)21-19/h1-9,14,20-21H,10-13H2
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InChIKey |
FWPAVENSJPMGJO-UHFFFAOYSA-N
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CAS Number |
CAS 221109-26-8
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [1] |
Voltage-gated potassium channel Kv11.1 (KCNH2) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Calcium signaling pathway | |||
Neuroactive ligand-receptor interaction | ||||
Gap junction | ||||
Serotonergic synapse | ||||
Inflammatory mediator regulation of TRP channels | ||||
Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
Pathwhiz Pathway | Muscle/Heart Contraction | |||
Reactome | Voltage gated Potassium channels | |||
Serotonin receptors | ||||
G alpha (q) signalling events | ||||
WikiPathways | SIDS Susceptibility Pathways | |||
Hematopoietic Stem Cell Differentiation | ||||
Potassium Channels | ||||
Serotonin Receptor 2 and STAT3 Signaling | ||||
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists. Bioorg Med Chem Lett. 2000 Dec 18;10(24):2701-3. | |||
REF 2 | 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists. J Med Chem. 2001 May 10;44(10):1603-14. |
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