Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08ECP
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| Former ID |
DIB020469
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| Drug Name |
N-[3H]alpha-methylhistamine
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| Synonyms |
N-alpha-methylhistamine; 1H-Imidazole-4-ethanamine, N-methyl-; 4-(2-Methylaminoethyl)imidazole; N(sup alpha)-Methylhistamine; NAMH; Nalpha-Methylhistamine; UNII-Y7QR253130; N(alpha)-methylhistamine; Y7QR253130; Imidazole, 4-[2-(methylamino)ethyl]-; Imidazole, 4-(2-(methylamino)ethyl)-; [2-(1H-imidazol-5-yl)ethyl](methyl)amine; 2-(3H-imidazol-4-yl)-N-methylethanamine; [3H]-Na-methylhistamine; [3H]NAMH; N-alpha-methyl histamine
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C6H11N3
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| Canonical SMILES |
CNCCC1=CN=CN1
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| InChI |
1S/C6H11N3/c1-7-3-2-6-4-8-5-9-6/h4-5,7H,2-3H2,1H3,(H,8,9)
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| InChIKey |
PHSPJQZRQAJPPF-UHFFFAOYSA-N
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| CAS Number |
CAS 673-50-7
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| PubChem Compound ID | ||||
| PubChem Substance ID |
5065181, 11113574, 15297184, 24439270, 26751779, 29215030, 47359864, 48105153, 49846344, 49846717, 49979813, 50831849, 57320585, 85177326, 85209211, 103100396, 103173300, 104296219, 117521462, 126406961, 126562153, 126581284, 126738242, 128917699, 131475502, 132630686, 134351295, 134978108, 135650394, 135650398, 136351124, 141951908, 142358121, 152045421, 164816575, 179293845, 184585654, 198969008, 226490982, 228232104, 243812317, 249209407, 249945440
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Agonist | [3] |
| Histamine H4 receptor (H4R) | Target Info | Agonist | [4] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1239). | |||
| REF 2 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1240). | |||
| REF 3 | Molecular and pharmacological characterization of the mouse histamine H3 receptor. Eur J Pharmacol. 2003 Apr 25;467(1-3):57-65. | |||
| REF 4 | Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. Br J Pharmacol. 2003 Nov;140(6):1117-27. | |||
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