Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08EIK
|
|||
| Former ID |
DIB012622
|
|||
| Drug Name |
LY3016859
|
|||
| Synonyms |
TGF-alpha.epiregulin mAb
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|
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| Indication | Chronic kidney disease [ICD-11: GB61; ICD-10: N18, N18.9] | Phase 1/2 | [1] | |
| Company |
Eli lilly
|
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Epiregulin (EREG) | Target Info | Modulator | [2] |
| Transforming growth factor alpha (TGFA) | Target Info | Modulator | [2] | |
| KEGG Pathway | ErbB signaling pathway | |||
| NetPath Pathway | FSH Signaling Pathway | |||
| EGFR1 Signaling Pathway | ||||
| Panther Pathway | EGF receptor signaling pathway | |||
| Pathway Interaction Database | ErbB4 signaling events | |||
| ErbB receptor signaling network | ||||
| Reactome | COPII (Coat Protein 2) Mediated Vesicle Transport | |||
| Cargo concentration in the ER | ||||
| SHC1 events in ERBB2 signaling | ||||
| PI3K events in ERBB4 signaling | ||||
| SHC1 events in ERBB4 signaling | ||||
| Nuclear signaling by ERBB4 | ||||
| PIP3 activates AKT signaling | ||||
| GRB2 events in ERBB2 signaling | ||||
| PI3K events in ERBB2 signaling | ||||
| Constitutive Signaling by Aberrant PI3K in Cancer | ||||
| RAF/MAP kinase cascade | ||||
| WikiPathways | ErbB Signaling Pathway | |||
| NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | ||||
| Extracellular vesicle-mediated signaling in recipient cells | ||||
| Signaling by ERBB4 | ||||
| Signaling by ERBB2 | ||||
| PIP3 activates AKT signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT01774981) Study of LY3016859 in Participants With Diabetic Nephropathy. U.S. National Institutes of Health. | |||
| REF 2 | Generation and activity of a humanized monoclonal antibody that selectively neutralizes the epidermal growth factor receptor ligands transforming growth factor-alpha and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43. | |||
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