Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08ESA
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| Former ID |
DIB006395
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| Drug Name |
CI-966
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| Synonyms |
1-[2-[Bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
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| Drug Type |
Small molecular drug
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| Indication | Convulsion [ICD-11: 8A68.Z; ICD-9: 780.3] | Phase 1 | [1], [2] | |
| Structure |
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Download2D MOL |
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| Formula |
C23H21F6NO3
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| Canonical SMILES |
C1CN(CC(=C1)C(=O)O)CCOC(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F
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| InChI |
1S/C23H21F6NO3/c24-22(25,26)18-7-3-15(4-8-18)20(16-5-9-19(10-6-16)23(27,28)29)33-13-12-30-11-1-2-17(14-30)21(31)32/h2-10,20H,1,11-14H2,(H,31,32)
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| InChIKey |
CMHQDSBIBSKHFP-UHFFFAOYSA-N
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| CAS Number |
CAS 110283-79-9
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| ChEBI ID |
CHEBI:93185
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA transporter GAT-1 (SLC6A1) | Target Info | Modulator | [2] |
| KEGG Pathway | GABAergic synapse | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4612). | |||
| REF 2 | Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24. | |||
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