Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08GPU
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| Former ID |
DNC003708
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| Drug Name |
5-Phenethyl-quinazoline-2,4-diamine
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| Synonyms |
CHEMBL341703; 5-phenethylquinazoline-2,4-diamine; 5-Phenethyl-quinazoline-2,4-diamine; AC1LALFL; CTK7E0789; BDBM50036483; ZINC13740535; 5-(2-phenylethyl)quinazoline-2,4-diamine; 5-(2-phenylethyl)-2,4-quinazolinediamine; 2,4-Diamino-5-(2-phenylethyl)-quinazoline; (2-amino-5-phenethyl-quinazolin-4-yl)-amine; 2,4-Quinazolinediamine, 5-(2-phenylethyl)-
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C16H16N4
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| Canonical SMILES |
C1=CC=C(C=C1)CCC2=C3C(=CC=C2)N=C(N=C3N)N
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| InChI |
1S/C16H16N4/c17-15-14-12(10-9-11-5-2-1-3-6-11)7-4-8-13(14)19-16(18)20-15/h1-8H,9-10H2,(H4,17,18,19,20)
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| InChIKey |
UIHMRPRVKDDARV-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Polypeptide deformylase (PDF) | Target Info | Inhibitor | [1] |
| Pathwhiz Pathway | Folate Metabolism | |||
| Pterine Biosynthesis | ||||
| Reactome | E2F mediated regulation of DNA replication | |||
| Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation | ||||
| Metabolism of folate and pterines | ||||
| G1/S-Specific Transcription | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dih... J Med Chem. 1995 Mar 3;38(5):745-52. | |||
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