Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08QIP
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| Former ID |
DAP000977
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| Drug Name |
Pranlukast
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| Synonyms |
Azlaire; Azlaire (TN); Pranlukast (INN); N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45; ICD-9: 493] | Approved | [1], [2] | |
| Therapeutic Class |
Antiasthmatic Agents
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| Structure |
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Download2D MOL |
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| Formula |
C27H23N5O4
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| Canonical SMILES |
C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5
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| InChI |
1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32)
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| InChIKey |
NBQKINXMPLXUET-UHFFFAOYSA-N
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| CAS Number |
CAS 103177-37-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
4500848, 14859100, 29223965, 50077761, 50077772, 50126316, 53786954, 77504954, 85220005, 91615698, 92308832, 92719276, 96025094, 96078242, 103188207, 103933734, 104307712, 125335358, 126620941, 126652683, 126670729, 128679004, 135072791, 135692295, 135698209, 137212400, 139795808, 144206505, 152106761, 162182220, 163032211, 164232709, 164826461, 175611959, 176484201, 177749374, 178100541, 179149492, 186010627, 196105989, 198972268, 210279434, 210281757, 223653303, 223704738, 225068984, 226395820, 250136802, 251887611, 252156957
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| ChEBI ID |
CHEBI:94810
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| SuperDrug ATC ID |
R03DC02
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| SuperDrug CAS ID |
cas=103177373
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Eubacteriales | ||||
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Studied Microbe: Ruminococcus bromii
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[3] | |||
| Hierarchy | ||||
| Abundance Change | Decrease | |||
| Experiment Method | High-throughput screening | |||
| Description | The abundance of Ruminococcus bromii was decreased by Pranlukast (adjusted p-values: 7.66E-03). | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Leukotriene CysLT1 receptor (CYSLTR1) | Target Info | Antagonist | [4] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| IL4 Signaling Pathway | ||||
| IL3 Signaling Pathway | ||||
| Pathway Interaction Database | Endothelins | |||
| Reactome | Leukotriene receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3634). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Extensive impact of non-antibiotic drugs on human gut bacteria. Nature. 2018 Mar 29;555(7698):623-628. | |||
| REF 4 | Beneficial effects of leukotriene receptor antagonists in the prevention of cedar pollinosis in a community setting. J Investig Allergol Clin Immunol. 2009;19(3):195-203. | |||
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