Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08QUV
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| Former ID |
DCL000340
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| Drug Name |
Amineptine
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| Synonyms |
Amineptin; Amineptino; Amineptinum; Amineptine [INN]; S 1694; Amineptine (INN); Amineptino [INN-Spanish]; Amineptinum [INN-Latin]; Survector (TN); 10,11-dihydrodibenzo(a,d)cyclohept-5-enyl-7-aminoheptanoic acid; 7-((10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)amino)heptanoic acid; 7-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylamino)heptanoic acid
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| Drug Type |
Small molecular drug
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| Indication | Major depressive disorder [ICD-11: 6A70.3; ICD-10: F32.2] | Withdrawn from market | [1] | |
| Company |
Roche
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| Structure |
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Download2D MOL |
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| Formula |
C22H27NO2
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| Canonical SMILES |
C1CC2=CC=CC=C2C(C3=CC=CC=C31)NCCCCCCC(=O)O
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| InChI |
1S/C22H27NO2/c24-21(25)13-3-1-2-8-16-23-22-19-11-6-4-9-17(19)14-15-18-10-5-7-12-20(18)22/h4-7,9-12,22-23H,1-3,8,13-16H2,(H,24,25)
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| InChIKey |
ONNOFKFOZAJDHT-UHFFFAOYSA-N
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| CAS Number |
CAS 57574-09-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
8147713, 8173876, 14976666, 34676485, 49975422, 50505586, 51091672, 57311733, 103327334, 104134025, 104319779, 117548871, 124894558, 126686143, 128834717, 134224457, 135002571, 137004292, 140010548, 142819018, 144206864, 162224697, 162875403, 163620999, 163686331, 164831173, 164835802, 179150696, 186022459, 198981995, 223674623, 226420608, 241100236, 250139127, 252477626
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| ChEBI ID |
CHEBI:32499
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| SuperDrug ATC ID |
N06AA19
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| SuperDrug CAS ID |
cas=057574091
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Dopamine transporter (DAT) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Dopaminergic synapse | |||
| Parkinson's disease | ||||
| Cocaine addiction | ||||
| Amphetamine addiction | ||||
| Alcoholism | ||||
| Panther Pathway | Adrenaline and noradrenaline biosynthesis | |||
| Parkinson disease | ||||
| Dopamine receptor mediated signaling pathway | ||||
| Pathway Interaction Database | Alpha-synuclein signaling | |||
| Reactome | Na+/Cl- dependent neurotransmitter transporters | |||
| WikiPathways | Monoamine Transport | |||
| NRF2 pathway | ||||
| Dopaminergic Neurogenesis | ||||
| Parkinsons Disease Pathway | ||||
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||||
| Neurotransmitter Clearance In The Synaptic Cleft | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | |||
| REF 2 | Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. J Med Assoc Thai. 1997 Sep;80(9):587-92. | |||
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