Drug Information
Drug General Information | Top | |||
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Drug ID |
D08RCH
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Former ID |
DNC009420
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Drug Name |
KF-A6
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Synonyms |
KF-A6; CHEMBL491889; SCHEMBL13438391; BDBM50249783
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C23H30N2O
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Canonical SMILES |
CCN(CC)CCCCCCN1C2=CC=CC=C2C(=O)C3=CC=CC=C31
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InChI |
1S/C23H30N2O/c1-3-24(4-2)17-11-5-6-12-18-25-21-15-9-7-13-19(21)23(26)20-14-8-10-16-22(20)25/h7-10,13-16H,3-6,11-12,17-18H2,1-2H3
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InChIKey |
YHXSELHUXJAOLR-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Histamine H1 receptor (H1R) | Target Info | Inhibitor | [1] |
Serotonin transporter (SERT) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Serotonergic synapse | |||
Calcium signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
Inflammatory mediator regulation of TRP channels | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | 5HT1 type receptor mediated signaling pathway | |||
5HT2 type receptor mediated signaling pathway | ||||
5HT3 type receptor mediated signaling pathway | ||||
5HT4 type receptor mediated signaling pathway | ||||
Histamine H1 receptor mediated signaling pathway | ||||
Reactome | Histamine receptors | |||
G alpha (q) signalling events | ||||
WikiPathways | Monoamine Transport | |||
SIDS Susceptibility Pathways | ||||
NRF2 pathway | ||||
Synaptic Vesicle Pathway | ||||
Serotonin Transporter Activity | ||||
Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | ||||
IL-4 Signaling Pathway | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. |
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