Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08TBU
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| Former ID |
DNC010157
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| Drug Name |
Diphenyl(piperidin-4-yl)methanol
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| Synonyms |
Azacyclonol; 115-46-8; diphenyl(piperidin-4-yl)methanol; alpha,alpha-diphenyl-4-piperidinomethanol; Frenquel; alpha,alpha-Diphenyl-4-piperidinemethanol; alpha-(4-Piperidyl)benzhydrol; gamma-Pipradol; Calmeran; Ataractan; Diphenyl-piperidin-4-yl-methanol; Diphenyl(4-piperidinyl)methanol; 4-Piperidinemethanol, alpha,alpha-diphenyl-; Azaciclonolo [DCIT]; Azacyklonol; Psychosan; MER 17; Frenoton; Azacyclonol [INN:BAN]; UNII-2MMR990PEM; Azacyclonolum [INN-Latin]; EINECS 204-092-5; Diphenyl-4-piperidylmethanol; BRN 0230221; 2MMR990PEM
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C18H21NO
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| Canonical SMILES |
C1CNCCC1C(C2=CC=CC=C2)(C3=CC=CC=C3)O
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| InChI |
1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
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| InChIKey |
ZMISODWVFHHWNR-UHFFFAOYSA-N
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| CAS Number |
CAS 115-46-8
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:93706
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H1 receptor (H1R) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | Histamine H1 receptor mediated signaling pathway | |||
| Reactome | Histamine receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Monoamine GPCRs | |||
| GPCRs, Class A Rhodopsin-like | ||||
| IL-4 Signaling Pathway | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5043-7. | |||
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