Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D08XYR
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| Former ID |
DNC013658
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| Drug Name |
DOM
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| Synonyms |
2,5-Dimethoxy-4-methylamphetamine; STP (hallucinogen); (RS)-DOM; DOM; 15588-95-1; dl-2,5-Dimethoxy-4-methylamphetamine; 2,5-Dimethoxymethylamphetamine; 4-Methyl-2,5-dimethoxyamphetamine; (+-)-DOM; dl-4-Methyl-2,5-dimethoxyamphetamine; 2',5'-Dimethoxy-4'-methylamphetamine; CHEMBL8600; (+-)-2,5-Dimethoxy-4-methylamphetamine; 2,5-Dimethoxy-4-methylphenylisopropylamine; 2,5-Dimethoxy-4,alpha-dimethylphenethylamin; DEA No. 7395; 2,5-Dimethoxy-alpha,4-dimethylphenylethylamine; 2-(2,5-Dimethoxy-4-methylphenyl)-2-aminopropane
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H19NO2
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| Canonical SMILES |
CC1=CC(=C(C=C1OC)CC(C)N)OC
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| InChI |
1S/C12H19NO2/c1-8-5-12(15-4)10(6-9(2)13)7-11(8)14-3/h5,7,9H,6,13H2,1-4H3
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| InChIKey |
NTJQREUGJKIARY-UHFFFAOYSA-N
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| CAS Number |
CAS 15588-95-1
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| PubChem Compound ID | ||||
| PubChem Substance ID |
7978580, 10221560, 10509196, 10516046, 15414462, 44417299, 46504804, 50004289, 57334104, 78158477, 85209384, 103111247, 103166957, 103918774, 104389663, 117533951, 124954066, 125705031, 128751983, 134350863, 134993569, 135650205, 137005387, 141288061, 160964775, 162821618, 179293624, 216396421, 226726881, 249527451, 249912022
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT 2A receptor (HTR2A) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Calcium signaling pathway | |||
| Neuroactive ligand-receptor interaction | ||||
| Gap junction | ||||
| Serotonergic synapse | ||||
| Inflammatory mediator regulation of TRP channels | ||||
| Panther Pathway | 5HT2 type receptor mediated signaling pathway | |||
| Reactome | Serotonin receptors | |||
| G alpha (q) signalling events | ||||
| WikiPathways | Serotonin Receptor 2 and STAT3 Signaling | |||
| Serotonin Receptor 2 and ELK-SRF/GATA4 signaling | ||||
| SIDS Susceptibility Pathways | ||||
| Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| GPCRs, Other | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 164). | |||
| REF 2 | The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorg Med Chem. 2008 Apr 15;16(8):4661-9. | |||
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