Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08YLW
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| Former ID |
DNC013103
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| Drug Name |
3-demethoxy-3-L-fucopyranosylaminothiocolchicine
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| Synonyms |
CHEMBL214151
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C27H34N2O8S
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| Canonical SMILES |
CC1C(C(C(C(O1)NC2=C(C(=C3C(=C2)CCC(C4=CC(=O)C(=CC=C43)SC)NC(=O)C)OC)OC)O)O)O
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| InChI |
1S/C27H34N2O8S/c1-12-22(32)23(33)24(34)27(37-12)29-18-10-14-6-8-17(28-13(2)30)16-11-19(31)20(38-5)9-7-15(16)21(14)26(36-4)25(18)35-3/h7,9-12,17,22-24,27,29,32-34H,6,8H2,1-5H3,(H,28,30)/t12-,17-,22+,23+,24-,27+/m0/s1
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| InChIKey |
ZYVFSIDQHJSZKV-MPHDHXMWSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| Glycine receptor (GlyR) | Target Info | Inhibitor | [1] | |
| Strychnine-binding glycine receptor (GLRA1) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 3-demethoxy-3-glycosylaminothiocolchicines: Synthesis of a new class of putative muscle relaxant compounds. J Med Chem. 2006 Sep 7;49(18):5571-7. | |||
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