Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09AMZ
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| Former ID |
DAP000597
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| Drug Name |
Enprofylline
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| Synonyms |
Enprofilina; Enprofyllinum; Nilyph; Oxeze; P 5679; D-4028; Enprofilina [INN-Spanish]; Enprofylline [USAN:INN]; Enprofyllinum [INN-Latin]; Enprofylline (USAN/INN); 3,7-Dihydro-3-propyl-1H-purine-2,6-dione; 3-Propyl-3,7-dihydro-purine-2,6-dione; 3-Propylxanthine; 3-n-Propylxanthine; 3-propyl-3,7-dihydro-1H-purine-2,6-dione; 3-propyl-7H-purine-2,6-dione
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| Drug Type |
Small molecular drug
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| Indication | Asthma [ICD-11: CA23; ICD-10: J45, J45.8; ICD-9: 493] | Approved | [1] | |
| Therapeutic Class |
Antiinflammatory Agents
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| Structure |
 |
Download2D MOL |
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| Formula |
C8H10N4O2
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| Canonical SMILES |
CCCN1C2=C(C(=O)NC1=O)NC=N2
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| InChI |
1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14)
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| InChIKey |
SIQPXVQCUCHWDI-UHFFFAOYSA-N
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| CAS Number |
CAS 41078-02-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
855784, 4285594, 8151233, 11111643, 12012874, 14772979, 15219898, 17398000, 17405468, 24277687, 26751510, 29220879, 46505790, 47365405, 47736695, 47810964, 48035338, 48110660, 50028023, 50100320, 50104067, 50104068, 53778016, 57320977, 72794359, 78817644, 85088984, 85209069, 85231189, 85331227, 90341781, 92304175, 103131576, 103188003, 103915958, 104171214, 104298395, 117600223, 121361566, 124750090, 124800765, 124881140, 124881141, 124881142, 124881143, 129241696, 132554404, 134222975, 134337888, 134338586
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| ChEBI ID |
CHEBI:126237
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Phosphodiesterase 4A (PDE4A) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Purine metabolism | |||
| cAMP signaling pathway | ||||
| Morphine addiction | ||||
| Reactome | DARPP-32 events | |||
| G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Effects of enprofylline, a new xanthine derivate, on human pregnant myometrium. Am J Obstet Gynecol. 1987 Apr;156(4):958-62. | |||
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