Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09AYK
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| Former ID |
DNC012999
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| Drug Name |
3-ethoxycarbonyl-4-quinolone
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| Synonyms |
ethyl 4-hydroxyquinoline-3-carboxylate; 26892-90-0; 52980-28-6; 4-Hydroxyquinoline-3-carboxylic acid ethyl ester; Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate; Ethyl 4-oxo-1,4-dihydro-3-quinolinecarboxylate; ethyl 1,4-dihydro-4-oxoquinoline-3-carboxylate; 3-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-, ethyl ester; ethyl 4-oxohydroquinoline-3-carboxylate; ethyl 4-oxo-1H-quinoline-3-carboxylate; 4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER; 4-Oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C12H11NO3
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| Canonical SMILES |
CCOC(=O)C1=CNC2=CC=CC=C2C1=O
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| InChI |
1S/C12H11NO3/c1-2-16-12(15)9-7-13-10-6-4-3-5-8(10)11(9)14/h3-7H,2H2,1H3,(H,13,14)
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| InChIKey |
YBEOYBKKSWUSBR-UHFFFAOYSA-N
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| CAS Number |
CAS 52980-28-6
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | GABA(A) receptor alpha-1 (GABRA1) | Target Info | Inhibitor | [1] |
| GABA(A) receptor beta-2 (GABRB2) | Target Info | Inhibitor | [1] | |
| GABA(A) receptor gamma-2 (GABRG2) | Target Info | Inhibitor | [1] | |
| Gamma-aminobutyric acid receptor (GAR) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Retrograde endocannabinoid signaling | ||||
| GABAergic synapse | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Serotonergic synapse | ||||
| Reactome | Ligand-gated ion channel transport | |||
| GABA A receptor activation | ||||
| WikiPathways | SIDS Susceptibility Pathways | |||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | ||||
| Iron uptake and transport | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | 4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore mod... J Med Chem. 2006 Apr 20;49(8):2526-33. | |||
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