Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09BNS
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| Former ID |
DIB018652
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| Drug Name |
5-hydroxy-L-tryptophan
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| Synonyms |
5-hydroxytryptophan
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL
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| Formula |
C11H12N2O3
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| Canonical SMILES |
C1=CC2=C(C=C1O)C(=CN2)CC(C(=O)O)N
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| InChI |
1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
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| InChIKey |
LDCYZAJDBXYCGN-VIFPVBQESA-N
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| CAS Number |
CAS 4350-09-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
3916, 3135071, 8144010, 10298279, 11111290, 14749139, 15121408, 15220427, 17388954, 17405189, 24278131, 24846778, 24880254, 25622038, 26752894, 26758904, 36883527, 46505826, 47885672, 48423586, 48425235, 49684260, 49854345, 50105515, 50105516, 51091676, 53777733, 56463305, 57402951, 78533373, 85165245, 87570920, 90340691, 90451647, 92297798, 92303940, 93617606, 103407870, 104620102, 108667067, 121278095, 121361400, 124550360, 124749869, 124799803, 124890389, 124890390, 124890391, 125311944, 126659668
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| ChEBI ID |
CHEBI:17780
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Solute carrier family 36 member 1 (SLC36A1) | Target Info | Inhibitor | [2] |
| Solute carrier family 36 member 2 (SLC36A2) | Target Info | Inhibitor | [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4671). | |||
| REF 2 | Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1. FASEB J. 2005 Sep;19(11):1468-73. | |||
| REF 3 | Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta. 2011 Jan;1808(1):260-70. | |||
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