Drug Information
Drug General Information | Top | |||
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Drug ID |
D09DJO
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Former ID |
DIB010552
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Drug Name |
Pafuramidine
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Synonyms |
Pafuramidine maleate; DB-289; DB-290; DB-75 prodrug, Immtech; Pafuramidine maleate (oral formulation), Strativa
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Drug Type |
Small molecular drug
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Indication | Malaria [ICD-11: 1F40-1F45; ICD-10: B50-B64, B54] | Phase 3 | [1] | |
Company |
Immtech International; University of North Carolina
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Structure |
Download2D MOL |
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Formula |
C20H20N4O3
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Canonical SMILES |
CON=C(C1=CC=C(C=C1)C2=CC=C(O2)C3=CC=C(C=C3)C(=NOC)N)N
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InChI |
1S/C20H20N4O3/c1-25-23-19(21)15-7-3-13(4-8-15)17-11-12-18(27-17)14-5-9-16(10-6-14)20(22)24-26-2/h3-12H,1-2H3,(H2,21,23)(H2,22,24)
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InChIKey |
UKOQVLAXCBRRGH-UHFFFAOYSA-N
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CAS Number |
CAS 186953-56-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Human Deoxyribonucleic acid (hDNA) | Target Info | Modulator | [2] |
References | Top | |||
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REF 1 | ClinicalTrials.gov (NCT00302341) DB289 Versus TMP-SMX for the Treatment of Acute Pneumocystis Jiroveci Pneumonia (PCP). U.S. National Institutes of Health. | |||
REF 2 | DNA Minor Groove Induced Dimerization of Heterocyclic Cations: Compound Structure, Binding Affinity and Specificity for a TTAA Site |
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