Drug Information
Drug General Information | Top | |||
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Drug ID |
D09ELW
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Former ID |
DNC000604
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Drug Name |
Enalkiren
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Synonyms |
ENALKIREN; Enalquireno; 113082-98-7; Abbott-64662; Enalkirenum [INN-Latin]; Enalkirene [INN-French]; Enalquireno [INN-Spanish]; Abbott 64662; Enalkiren [USAN:INN]; UNII-0U7YZ42Z47; A-64662; CHEMBL300337; CHEBI:4787; 0U7YZ42Z47; A 64662; (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide; Enalkirenum; Enalkirene
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Drug Type |
Small molecular drug
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Indication | Glaucoma/ocular hypertension [ICD-11: 9C61; ICD-9: 365] | Discontinued in Phase 2 | [1] | |
Structure |
Download2D MOL |
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Formula |
C35H56N6O6
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Canonical SMILES |
CC(C)CC(C(C(CC1CCCCC1)NC(=O)C(CC2=CN=CN2)NC(=O)C(CC3=CC=C(C=C3)OC)NC(=O)CC(C)(C)N)O)O
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InChI |
1S/C35H56N6O6/c1-22(2)15-30(42)32(44)27(16-23-9-7-6-8-10-23)40-34(46)29(18-25-20-37-21-38-25)41-33(45)28(39-31(43)19-35(3,4)36)17-24-11-13-26(47-5)14-12-24/h11-14,20-23,27-30,32,42,44H,6-10,15-19,36H2,1-5H3,(H,37,38)(H,39,43)(H,40,46)(H,41,45)/t27-,28-,29-,30-,32+/m0/s1
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InChIKey |
KQXVERRYBYGQJZ-WRPDIKACSA-N
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CAS Number |
CAS 113082-98-7
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PubChem Compound ID | ||||
PubChem Substance ID | ||||
ChEBI ID |
CHEBI:4787
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Target and Pathway | Top | |||
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Target(s) | Angiotensinogenase renin (REN) | Target Info | Inhibitor | [2] |
KEGG Pathway | Renin-angiotensin system | |||
Pathwhiz Pathway | Angiotensin Metabolism | |||
Reactome | Metabolism of Angiotensinogen to Angiotensins | |||
WikiPathways | ACE Inhibitor Pathway | |||
Metabolism of Angiotensinogen to Angiotensins |
References | Top | |||
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REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000369) | |||
REF 2 | Comparative effects of three different potent renin inhibitors in primates. Hypertension. 1993 Jul;22(1):9-17. |
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