Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09NAW
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| Former ID |
DIB001866
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| Drug Name |
PF-05105679
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| Indication | Pain [ICD-11: MG30-MG3Z] | Phase 1 | [1] | |
| Company |
Pfizer Inc
|
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| Structure |
 |
Download2D MOL |
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| Formula |
C26H21FN2O3
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| Canonical SMILES |
CC(C1=CC=C(C=C1)F)N(CC2=CC(=CC=C2)C(=O)O)C(=O)C3=CC4=CC=CC=C4N=C3
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| InChI |
1S/C26H21FN2O3/c1-17(19-9-11-23(27)12-10-19)29(16-18-5-4-7-21(13-18)26(31)32)25(30)22-14-20-6-2-3-8-24(20)28-15-22/h2-15,17H,16H2,1H3,(H,31,32)/t17-/m1/s1
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| InChIKey |
BXNMZRPTQFVRFA-QGZVFWFLSA-N
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| CAS Number |
CAS 1398583-31-7
|
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Long transient receptor potential channel 8 (TRPM8) | Target Info | Modulator | [1] |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | |||
| Reactome | TRP channels | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. | |||
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