Drug Information
Drug General Information | Top | |||
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Drug ID |
D09NWW
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Former ID |
DIB013331
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Drug Name |
AMG-247
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Synonyms |
AMG-369; Multiple sclerosis therapeutics, Amgen; S1P1 receptor antagonists (multiple sclerosis/inflammation); S1P1 receptor antagonists (multiple sclerosis/inflammation), Amgen
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Indication | Inflammation [ICD-11: 1A00-CA43.1] | Investigative | [1] | |
Company |
Amgen Inc
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Structure |
Download2D MOL |
Target and Pathway | Top | |||
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Target(s) | Sphingosine-1-phosphate receptor 1 (S1PR1) | Target Info | Antagonist | [1] |
KEGG Pathway | FoxO signaling pathway | |||
Sphingolipid signaling pathway | ||||
Neuroactive ligand-receptor interaction | ||||
NetPath Pathway | IL4 Signaling Pathway | |||
TGF_beta_Receptor Signaling Pathway | ||||
IL2 Signaling Pathway | ||||
Pathway Interaction Database | Fc-epsilon receptor I signaling in mast cells | |||
S1P3 pathway | ||||
S1P1 pathway | ||||
Sphingosine 1-phosphate (S1P) pathway | ||||
PDGFR-beta signaling pathway | ||||
Reactome | G alpha (i) signalling events | |||
Lysosphingolipid and LPA receptors | ||||
WikiPathways | Signal Transduction of S1P Receptor | |||
Small Ligand GPCRs | ||||
GPCR ligand binding | ||||
GPCR downstream signaling | ||||
GPCRs, Other |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275). |
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