Drug Information
Drug General Information | Top | |||
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Drug ID |
D09OBB
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Former ID |
DAP000277
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Drug Name |
Dextromethorphan
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Synonyms |
Albutussin; Canfodion; Cosylan; Demorphine; Destrometerfano; Dextromethorfan; Dextromethorphane; Dextromethorphanum; Dextrometorfano; Dextrometorphan; Dextromorphan; Dexyromethorphan; Dormetan; Levomethorphan; Levomethorphane; Levomethorphanum; Levometorfano; Methorphan; RACEMETHORPHAN; Trocal; Balminil DM; Balminil DM Children; Benylin Adult Formula Cough Suppressant; Benylin DM for Children; Benylin Pediatric Cough Suppressant; Delsym Cough Formula; Demorphan hydrobromide; Destrometerfano [DCIT]; Dextromethorfan [Czech]; Dextromethorphan Bromhydrate; Hold DM; Koffex DM; Novahistex DM; Novahistine DM; Pertussin DM Extra Strength; Robitussin Maximum Strength Cough Suppressant; Robitussin Pediatric; Robitussin Pediatric Cough Suppressant; Triaminic DM Long Lasting for Children; BA 2666; Benylin DM 12 Hour; Benylin DM for Children 12 Hour; Sucrets 4 Hour Cough Suppressant; Vicks 44 Cough Relief; Calmylin #1; Cough-X; Creo-Terpin; D-Methorphan; Delta-Methorphan; Dextromethorphan (USP); Dextromethorphane [INN-French]; Dextromethorphanum [INN-Latin]; Dextrometorfano [INN-Spanish]; Diabe-Tuss DM Syrup; Hihustan M.; L-Methorphan; Levomethorphane [INN-French]; Levomethorphanum [INN-Latin]; Levometorfano [INN-Spanish]; Neurodex (TN); Pertussin CS Children's Strength; Romilar (TN); Dextromethorphan [USP:INN:BAN]; Levomethorphan [BAN:DCF:INN]; Levomethorphan [INN:BAN:DCF]; Morphinan, 3-methoxy-17-methyl-, (9-alpha,13-alpha,14-alpha)-(9CI); Cis-1,3,4,9,10,10a-Hexahydro-6-methoxy-11-methyl-2H-10,4alpha-iminoethanophenanthren; (+)-3-Methoxy-17-methylmorphinan; (-)-3-Methoxy-N-methylmorphinan; (9alpha,13alpha,14alpha)-17-methyl-3-(methyloxy)morphinan; 3-Methoxy-17-methyl-9alpha,13alpha,14alpha-morphinan; 3-Methoxy-17-methylmorphinan; 3-Methoxy-N-methylmorphinon; 9alpha,13alpha,14alpha-Morphinan, 3-methoxy-17-methyl-(8CI)
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Drug Type |
Small molecular drug
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Indication | Cough [ICD-11: MD12; ICD-10: R05] | Approved | [1], [2] | |
Therapeutic Class |
Analgesics
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Structure |
Download2D MOL |
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Formula |
C18H25NO
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Canonical SMILES |
CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC
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InChI |
1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
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InChIKey |
MKXZASYAUGDDCJ-NJAFHUGGSA-N
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CAS Number |
CAS 125-71-3
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PubChem Compound ID | ||||
PubChem Substance ID |
9162, 841236, 7979054, 11111057, 11466387, 11467507, 11486114, 11653778, 14750569, 15197408, 17397831, 36162350, 47589233, 47736760, 48110733, 48259500, 48415868, 49698454, 49992848, 50100218, 53788221, 78345542, 85788569, 92309044, 103234890, 104032183, 134337591, 135269894, 136105653, 137004970, 139157561, 160845715, 160963859, 163134005, 175267045, 176484334, 178103535, 179081907, 184546015, 198952691, 223553926, 223796778, 226416902, 249865619, 250137237, 252347944, 252818368
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ChEBI ID |
CHEBI:4470
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ADReCS Drug ID | BADD_D00638 | |||
SuperDrug ATC ID |
R05DA09
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SuperDrug CAS ID |
cas=000125713
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Target and Pathway | Top | |||
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Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Agonist | [3] |
WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
miR-targeted genes in lymphocytes - TarBase |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6953). | |||
REF 2 | Molecular insights and therapeutic targets in amyotrophic lateral sclerosis. CNS Neurol Disord Drug Targets. 2008 Feb;7(1):11-9. | |||
REF 3 | Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7. |
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