Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09OQZ
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| Drug Name |
PMID25435285-Compound-49
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| Drug Type |
Small molecular drug
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| Company |
F. HOFFMANN-LA ROCHE AG GATTI MCARTHUR, Silvia WICHMANN, Juergen WOLTERING, Thomas
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| Structure |
 |
Download2D MOL |
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| Formula |
C21H13ClF3N3O2S2
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| Canonical SMILES |
C1=CC(=CC(=C1)C2=NC(=CC(=N2)C(F)(F)F)C3=CC=C(S3)Cl)C4=CC(=CC=C4)S(=O)(=O)N
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| InChI |
1S/C21H13ClF3N3O2S2/c22-19-8-7-17(31-19)16-11-18(21(23,24)25)28-20(27-16)14-5-1-3-12(9-14)13-4-2-6-15(10-13)32(26,29)30/h1-11H,(H2,26,29,30)
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| InChIKey |
PNTBWHIVXJKWAT-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Antagonist | [1] |
| Target's Patent Info | Metabotropic glutamate receptor 2 (mGluR2) | Target's Patent Info | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Glutamatergic synapse | ||||
| Cocaine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Reactome | G alpha (i) signalling events | |||
| Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
| WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. | |||
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