Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09OTG
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| Former ID |
DCL000888
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| Drug Name |
MS-377
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| Synonyms |
MS-377; SCHEMBL466934; DKVVPXLIRYCKCS-OAHLLOKOSA-N; AKOS003589066; (R)-1-(4-chlorophenyl)-3-(4-(2-methoxyethyl)piperazin-1-yl)methyl-2-pyrrolidinone; (r)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone
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| Drug Type |
Small molecular drug
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| Indication | Schizophrenia [ICD-11: 6A20] | Terminated | [1] | |
| Company |
Schering AG
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| Structure |
 |
Download2D MOL |
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| Formula |
C18H26ClN3O2
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| Canonical SMILES |
COCCN1CCN(CC1)CC2CCN(C2=O)C3=CC=C(C=C3)Cl
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| InChI |
1S/C18H26ClN3O2/c1-24-13-12-20-8-10-21(11-9-20)14-15-6-7-22(18(15)23)17-4-2-16(19)3-5-17/h2-5,15H,6-14H2,1H3/t15-/m1/s1
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| InChIKey |
DKVVPXLIRYCKCS-OAHLLOKOSA-N
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| SuperDrug ATC ID |
J01GB10
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| SuperDrug CAS ID |
cas=025546650
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor sigma 1 (OPRS1) | Target Info | Antagonist | [1] |
| WikiPathways | miR-targeted genes in squamous cell - TarBase | |||
| miR-targeted genes in lymphocytes - TarBase | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. | |||
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