Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09ROG
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| Former ID |
DNC009091
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| Drug Name |
UCL-2138
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| Synonyms |
UCL-2138; CHEMBL129257; 4-(3-piperidin-1-ylpropoxy)benzonitrile; Benzonitrile, 4-[3-(1-piperidinyl)propoxy]-; 146440-20-2; AC1MGZLJ; ACMC-20n4tz; SCHEMBL491825; GTPL1257; CTK0B2418; DTXSID60388154; UCL2138; ZINC2009079; UCL 2138; PDSP2_000689; BDBM50133003; PDSP1_000699; AKOS009440882; MCULE-6416627117; 4-[3-(1-Piperidinyl)propoxy]benzonitrile; 4-(3-Piperidin-1-yl-propoxy)-benzonitrile; 4-(3-(piperidin-1-yl)propoxy)benzonitrile
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C15H20N2O
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| Canonical SMILES |
C1CCN(CC1)CCCOC2=CC=C(C=C2)C#N
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| InChI |
1S/C15H20N2O/c16-13-14-5-7-15(8-6-14)18-12-4-11-17-9-2-1-3-10-17/h5-8H,1-4,9-12H2
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| InChIKey |
RHMNKKOAWUCDRK-UHFFFAOYSA-N
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| CAS Number |
CAS 146440-20-2
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| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Histamine H3 receptor (H3R) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Reactome | Histamine receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | Monoamine Transport | |||
| GPCRs, Class A Rhodopsin-like | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1257). | |||
| REF 2 | Fluorinated non-imidazole histamine H3 receptor antagonists. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2172-5. | |||
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