Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09VHW
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| Former ID |
DNC001400
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| Drug Name |
T-1105
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| Synonyms |
3-Hydroxypyrazine-2-carboxamide; 55321-99-8; 2-oxo-1H-pyrazine-3-carboxamide; 3-Oxo-3,4-dihydropyrazine-2-carboxamide; Pyrazinecarboxamide, 3,4-dihydro-3-oxo-; NSC163503; SZPBAPFUXAADQV-UHFFFAOYSA-N; Pyrazine-2-carboxamide, 3-hydroxy-; t6mv dnj cvz[wln]; 3-HYDROXYPYRAZINE-2-CARBOXAMINE; AC1Q6FTJ; AC1L6MD7; KSC273I6F; SCHEMBL1338425; ZINC8657; 3-Hydroxy-2-pyrazinecarboxamide; CTK1H3462; DTXSID10203888; 3-hydroxy-pyrazine-2-carboxamide; MolPort-005-980-549; 3-Hydroxy-2-pyrazinecarboxamide #
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1], [2], [3] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C5H5N3O2
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| Canonical SMILES |
C1=CN=C(C(=O)N1)C(=O)N
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| InChI |
1S/C5H5N3O2/c6-4(9)3-5(10)8-2-1-7-3/h1-2H,(H2,6,9)(H,8,10)
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| InChIKey |
SZPBAPFUXAADQV-UHFFFAOYSA-N
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| CAS Number |
CAS 55321-99-8
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| PubChem Compound ID | ||||
| PubChem Substance ID |
438328, 6849770, 10526894, 22425483, 24533086, 34834568, 58107224, 75584819, 93347762, 95507920, 103850010, 104178968, 104495128, 109714169, 117592920, 123052943, 124338935, 125569291, 126540661, 126596935, 126597038, 126634454, 126686454, 134340459, 134340587, 135263680, 136994507, 137212757, 140218083, 141255437, 142027429, 143454897, 144104263, 152090320, 152222936, 152343795, 160799794, 162138955, 162194449, 162550668, 163372353, 163805723, 164044973, 164777177, 170558691, 179109491, 180682096, 184592765, 186006921, 201500073
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Virus RNA-dependent RNA polymerase (Viru RdRP) | Target Info | Inhibitor | [1], [2], [3] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother. 2009 Jan;53(1):202-9. | |||
| REF 2 | PA subunit of RNA polymerase as a promising target for anti-influenza virus agents. Antiviral Res. 2008 Jun;78(3):194-201. | |||
| REF 3 | Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25. | |||
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