Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09WNK
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| Former ID |
DAP001478
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| Drug Name |
Fenfluramine
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| Synonyms |
Acino; Adifax; Adipomin; Fenfluramina; Fenfluraminum; Isomeride; Obedrex; Pesos; Ponderex; Rotondin; Dexfenfluramina [Spanish]; Dexfenfluraminum [Latin]; Fenfluramina [DCIT]; Fenfluramine hydrochloride; Levofenfluramine [INN]; Ponderax PA; S 768; D-Fenfluramine; Dexfenfluramine [INN:BAN]; Fenfluramine (INN); Fenfluramine [INN:BAN]; Fenfluraminum [INN-Latin]; Ponderax (TN); Fenfluramine, (+-)-Isomer; N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine; D-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine; N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine; N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine; N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-(9CI); Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (S)-(9CI);Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (+-)-(9CI); (+)-Fenfluramine; (+-)-Fenfluramine; (+/-)-Fenfluramine hydrochloride; (S)-Fenfluramine; 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane; 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane; 2-Ethylamino-1-(3-trifluoromethylphenyl)propane; 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine
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| Drug Type |
Small molecular drug
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| Indication | Dravet syndrome [ICD-11: 8A61.11] | Phase 3 | [1], [2] | |
| LennoxGastaut syndrome [ICD-11: 8A62.1] | Phase 3 | [1] | ||
| Obesity [ICD-11: 5B81; ICD-10: E66; ICD-9: 278] | Withdrawn from market | [3], [4] | ||
| Company |
Zogenix Emeryville, CA
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| Structure |
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Download2D MOL |
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| Formula |
C12H16F3N
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| Canonical SMILES |
CCNC(C)CC1=CC(=CC=C1)C(F)(F)F
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| InChI |
1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3
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| InChIKey |
DBGIVFWFUFKIQN-UHFFFAOYSA-N
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| CAS Number |
CAS 458-24-2
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9209, 3249386, 5309215, 8152120, 10321808, 10523352, 11336155, 11361394, 11462366, 15172399, 29215428, 29222472, 46506096, 48259332, 48416003, 50004501, 50004502, 50004503, 50109858, 50109859, 57321735, 77105779, 85209461, 92714658, 92729648, 96024640, 99313648, 103293190, 104303215, 117434287, 117434288, 124360345, 124892216, 125823537, 126629461, 126688542, 127709649, 134338464, 134338672, 134973127, 135120528, 136350838, 137100754, 139029041, 144205250, 148028517, 160963919, 164788577, 178101333, 179148561
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| ChEBI ID |
CHEBI:5000
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| SuperDrug ATC ID |
A08AA02
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| SuperDrug CAS ID |
cas=000458242
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Metabolism of Drug Affected by Studied Microbe(s) | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Gut microbiota | ||||
| Studied Microbe: Gut microbiota unspecific | [5], [6] | |||
| Metabolic Reaction | Deglycosylation | |||
| Resulting Metabolite | Phenolic acids | |||
| Description | Fenfluramine can be metabolized to Phenolic acids by gut microbiota through deglycosylation. | |||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | 5-HT receptor (5HTR) | Target Info | Antagonist | [7] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 2 | Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA) | |||
| REF 3 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4613). | |||
| REF 4 | Obesity: pathophysiology and clinical management. Curr Med Chem. 2009;16(4):506-21. | |||
| REF 5 | Gut Microbiota-Mediated Drug-Antibiotic Interactions. Drug Metab Dispos. 2015 Oct;43(10):1581-9. | |||
| REF 6 | Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch Pharm Res. 1998 Feb;21(1):17-23. | |||
| REF 7 | Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418. | |||
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