Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09WSG
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| Former ID |
DNC008135
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| Drug Name |
Salvinorin B benzyloxymethyl ether
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| Synonyms |
CHEMBL271061; salvinorin B benzyloxymethyl ether
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C29H34O8
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| Canonical SMILES |
CC12CCC3C(=O)OC(CC3(C1C(=O)C(CC2C(=O)OC)OCOCC4=CC=CC=C4)C)C5=COC=C5
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| InChI |
1S/C29H34O8/c1-28-11-9-20-27(32)37-23(19-10-12-34-16-19)14-29(20,2)25(28)24(30)22(13-21(28)26(31)33-3)36-17-35-15-18-7-5-4-6-8-18/h4-8,10,12,16,20-23,25H,9,11,13-15,17H2,1-3H3/t20-,21-,22-,23-,25-,28-,29-/m0/s1
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| InChIKey |
UEIIMJAHRTUJMW-ZZIVESEQSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Opioid receptor kappa (OPRK1) | Target Info | Inhibitor | [1] |
| KEGG Pathway | Neuroactive ligand-receptor interaction | |||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
| Opioid prodynorphin pathway | ||||
| Reactome | Peptide ligand-binding receptors | |||
| G alpha (i) signalling events | ||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | |||
| Peptide GPCRs | ||||
| GPCR ligand binding | ||||
| GPCR downstream signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. | |||
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