Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D09WVV
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| Former ID |
DNC011081
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| Drug Name |
N1-(2-aminoethyl)ethane-1,2-diamine
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| Synonyms |
DIETHYLENETRIAMINE; 111-40-0; Bis(2-aminoethyl)amine; 2,2'-Diaminodiethylamine; Diethylene triamine; Barsamide 115; Epicure T; Ancamine DETA; 1,4,7-Triazaheptane; 2,2'-Iminodiethylamine; N,N-Bis(2-aminoethyl)amine; Aminoethylethandiamine; 3-Azapentane-1,5-diamine; 1,2-Ethanediamine, N-(2-aminoethyl)-; Imino-bis-ethylamine; ChS-P 1; N-(2-Aminoethyl)-1,2-ethanediamine; N-(2-aminoethyl)ethane-1,2-diamine; 1,5-Diamino-3-azapentane; 2,2'-Iminobis(ethanamine); Bis(beta-aminoethyl)amine; 2-(2-Aminoethylamino)ethylamine; Epon 3223
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C4H13N3
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| Canonical SMILES |
C(CNCCN)N
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| InChI |
1S/C4H13N3/c5-1-3-7-4-2-6/h7H,1-6H2
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| InChIKey |
RPNUMPOLZDHAAY-UHFFFAOYSA-N
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| CAS Number |
CAS 111-40-0
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:30629
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Carbonic anhydrase (CA) | Target Info | Inhibitor | [1] |
| Carbonic anhydrase IX (CA-IX) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase VI (CA-VI) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase XII (CA-XII) | Target Info | Inhibitor | [1] | |
| Carbonic anhydrase XIV (CA-XIV) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | Nitrogen metabolism | |||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | |||
| Reactome | Reversible hydration of carbon dioxide | |||
| Regulation of gene expression by Hypoxia-inducible Factor | ||||
| WikiPathways | Reversible Hydration of Carbon Dioxide | |||
| miR-targeted genes in muscle cell - TarBase | ||||
| miR-targeted genes in leukocytes - TarBase | ||||
| miR-targeted genes in epithelium - TarBase | ||||
| Vitamin D Receptor Pathway | ||||
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. | |||
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